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Tailorable cationic chitosan/PLGA nanoparticles (CPNP) were used for the delivery of an antisense 2′- O-methyl-RNA (2OMR) directed against RNA template of human telomerase. Here, we describe the influence of the chitosan content on binding efficiency, complex stability, uptake in different human lung cell types and finally demonstrate the efficacy of this nanoplex system.CPNPs were prepared by t..

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